General Information

  • ID:  hor003405
  • Uniprot ID:  E9HBU8
  • Protein name:  Orcokinin 1
  • Gene name:  NA
  • Organism:  Daphnia pulex (Water flea)
  • Family:  Orcokinin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Daphnia (genus), Daphniidae (family), Anomopoda (infraorder), Cladocera (suborder), Diplostraca (order), Phyllopoda (subclass), Branchiopoda (class), Crustacea (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005184 neuropeptide hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  NA

Sequence Information

  • Sequence:  NLDEIDRSNFGTFA
  • Length:  14(105-118)
  • Propeptide:  MNCLKFRLVAVAILIFNVVTALNYQSEEAVGVEHERDRDSLGGGHILRGLDSIGESNLLRAIYREKPRDFLRINRGLDSLSGASFGIEKRLDSLTGLGFGSQKRNLDEIDRSNFGTFAKRNLDEIDRSDFGRFVKKRETMEAESSQQQH
  • Signal peptide:  MNCLKFRLVAVAILIFNVVTA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Myotropic
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-E9HBU8-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor003405_AF2.pdbhor003405_ESM.pdb

Physical Information

Mass: 183075 Formula: C69H103N19O25
Absent amino acids: CHKMPQVWY Common amino acids: DFN
pI: 3.88 Basic residues: 1
Polar residues: 5 Hydrophobic residues: 5
Hydrophobicity: -58.57 Boman Index: -3987
Half-Life: 1.4 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 62.86
Instability Index: 4105.71 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  21830762
  • Title:  Genomics, Transcriptomics, and Peptidomics of Daphnia Pulex Neuropeptides and Protein Hormones